Quarterly report pursuant to Section 13 or 15(d)

Intangible Assets - Components of Intangible Assets (Details)

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Intangible Assets - Components of Intangible Assets (Details) - USD ($)
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2017
Intangible assets consist of:      
Intangible assets, net $ 1,058,346   $ 936,992
Patent costs 22,000    
Amortization of Intangible Assets 19,600 $ 23,189  
Future amortization of license and patent agreements      
Remainder of this year 63,000    
2019 84,000    
2020 84,000    
2021 84,000    
2022 84,000    
2023 84,000    
2024 84,000    
After 2024 76,000    
License Agreements      
Intangible assets consist of:      
Finite-lived intangible assets, gross 1,007,566   1,007,566
Less: accumulated amortization (547,202)   (485,585)
Intangible assets, net $ 460,364   521,981
License Agreements | Minimum      
Intangible assets consist of:      
Amortization period of intangible assets 17 years    
License Agreements | Maximum      
Intangible assets consist of:      
Amortization period of intangible assets 20 years    
Patents      
Intangible assets consist of:      
Finite-lived intangible assets, gross $ 645,749   459,903
Less: accumulated amortization (47,767)   (44,892)
Intangible assets, net $ 597,982   $ 415,011
Amortization period of intangible assets 3 years    
Pending and issued license costs $ 624,000    
Pending and issued license costs amortized over period of 20 years $ 102,000    
Patents | Maximum      
Intangible assets consist of:      
Amortization period of intangible assets 20 years