Quarterly report pursuant to Section 13 or 15(d)

Intangible Assets - Components of Intangible Assets (Details)

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Intangible Assets - Components of Intangible Assets (Details) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Dec. 31, 2017
Intangible assets consist of:          
Intangible assets, net $ 1,157,521   $ 1,157,521   $ 936,992
Patent costs     22,000    
Amortization of Intangible Assets 20,000 $ 19,000 39,715 $ 41,706  
Future amortization of license and patent agreements          
Remainder of fiscal year 2018 47,000   47,000    
2019 81,000   81,000    
2020 81,000   81,000    
2021 81,000   81,000    
2022 81,000   81,000    
2023 81,000   81,000    
2024 81,000   81,000    
After 2024 59,000   59,000    
License Agreements          
Intangible assets consist of:          
Finite-lived intangible assets, gross 1,010,065   1,010,065   1,007,566
Less: accumulated amortization (519,036)   (519,036)   (485,585)
Intangible assets, net 491,029   $ 491,029   521,981
License Agreements | Minimum          
Intangible assets consist of:          
Amortization period of intangible assets     17 years    
License Agreements | Maximum          
Intangible assets consist of:          
Amortization period of intangible assets     20 years    
Patents          
Intangible assets consist of:          
Finite-lived intangible assets, gross 717,649   $ 717,649   459,903
Less: accumulated amortization (51,157)   (51,157)   (44,892)
Intangible assets, net $ 666,492   $ 666,492   $ 415,011
Amortization period of intangible assets     3 years    
Pending and issued license costs     $ 711,000    
Pending and issued license costs amortized over period of 20 years     $ 115,000    
Patents | Maximum          
Intangible assets consist of:          
Amortization period of intangible assets     20 years