Quarterly report pursuant to Section 13 or 15(d)

Intangible Assets - Components of Intangible Assets (Details)

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Intangible Assets - Components of Intangible Assets (Details) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Intangible assets consist of:        
Intangible assets, net   $ 1,198,131   $ 936,992
Patent costs   22,000    
Amortization of Intangible Assets $ 19,000 58,550 $ 60,459  
Future amortization of license and patent agreements        
Remainder of fiscal year 2018   19,000    
2019   75,000    
2020   75,000    
2021   75,000    
2022   75,000    
2023   75,000    
2024   75,000    
After 2024   60,000    
License Agreements        
Intangible assets consist of:        
Finite-lived intangible assets, gross   1,033,591   1,007,566
Less: accumulated amortization   (535,762)   (485,585)
Intangible assets, net   $ 497,829   521,981
License Agreements | Minimum        
Intangible assets consist of:        
Amortization period of intangible assets   17 years    
License Agreements | Maximum        
Intangible assets consist of:        
Amortization period of intangible assets   20 years    
Patents        
Intangible assets consist of:        
Finite-lived intangible assets, gross   $ 753,567   459,903
Less: accumulated amortization   (53,265)   (44,892)
Intangible assets, net   $ 700,302   $ 415,011
Amortization period of intangible assets   3 years    
Pending and issued license costs   $ 745,000    
Pending and issued license costs amortized over period of 20 years   $ 69,000    
Patents | Maximum        
Intangible assets consist of:        
Amortization period of intangible assets   20 years