Quarterly report pursuant to Section 13 or 15(d)

Intangible Assets - Components of Intangible Assets (Details)

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Intangible Assets - Components of Intangible Assets (Details) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Dec. 31, 2016
Intangible assets consist of:          
Less: accumulated amortization $ (513,751)   $ (513,751)   $ (463,575)
Intangible assets, net 951,473   951,473   828,979
Patent costs     22,000    
Amortization of Intangible Assets 19,000 $ 16,000 60,459 $ 48,050  
Future amortization of license and patent agreements          
Remainder of this year 19,000   19,000    
Next five years 74,000   74,000    
After year five 563,000   563,000    
License Agreements          
Intangible assets consist of:          
Finite-lived intangible assets, gross 1,003,512   $ 1,003,512   984,342
License Agreements | Minimum          
Intangible assets consist of:          
Amortization period of intangible assets     17 years    
License Agreements | Maximum          
Intangible assets consist of:          
Amortization period of intangible assets     20 years    
Patents          
Intangible assets consist of:          
Finite-lived intangible assets, gross $ 461,712   $ 461,712   $ 308,212
Amortization period of intangible assets     3 years    
Non-amortizable pending costs     $ 461,712    
Patents | Maximum          
Intangible assets consist of:          
Amortization period of intangible assets     20 years